Overview
- The draw in Nyon produced eight two-legged ties for the knockout round play-offs, finalizing the bracket for progression to the last 16.
- Crystal Palace, seeded after finishing 10th in the league phase, will host the second leg at Selhurst Park against Zrinjski, who placed 23rd.
- If Palace progress, they are slated to meet either Mainz or AEK Larnaca in March's round of 16 based on the predetermined bracket.
- Other ties include Jagiellonia vs Fiorentina, Noah vs AZ Alkmaar, KuPS vs Lech Poznań, Sigma Olomouc vs Lausanne-Sport, Drita vs Celje, Omonoia vs Rijeka, and Shkëndija vs Samsunspor.
- The round-of-16 draw is scheduled for February 27, with the competition culminating in the final on May 27 in Leipzig.