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Scripps Research to Test Ribose Phosphorylation in Protocells

Investigators will examine whether ribose’s preferential reaction with diamidophosphate can yield nucleotide precursors that generate membrane tension for protocell development.

Overview

  • A June 27 Angewandte Chemie study confirmed diamidophosphate phosphorylates ribose faster than other pentoses under prebiotic conditions
  • NMR spectroscopy revealed ribose reactions produce exclusively five-member ring structures matching the sugar backbone of modern RNA and DNA
  • Mixed-sugar experiments showed DAP selectively enriched ribose and advanced it to a nucleotide-ready form while arabinose, lyxose and xylose stalled
  • Researchers emphasize that these findings offer plausible prebiotic pathways without claiming definitively to explain RNA’s emergence
  • Next steps involve replicating these phosphorylation processes inside primitive membrane-bound protocells to test their roles in driving growth or division