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Rugged, Low-Cost FlightScope Microscope Captures Live Cells in Microgravity on ESA Parabolic Flight

The open-source–derived instrument offers low-cost, real-time cell imaging in microgravity for labs beyond the ISS.

Overview

  • Built by Newcastle University from a Stanford open-source design, FlightScope is engineered for zero- and microgravity research at a fraction of traditional costs.
  • During an ESA parabolic flight, the system imaged yeast taking up fluorescent glucose, with uptake appearing slower in weightlessness than under normal gravity.
  • To withstand violent flight maneuvers, the team added rigid mountings, vibration dampening, and a custom fluid-handling module for rapid experiment switching.
  • The researchers are releasing the design to broaden access to space biology experiments that require live-cell microscopy.
  • The work was published in npj Microgravity, showcased at the Biophysical Society meeting, extended to Boulby salt mine studies of archaea, and is being adapted for a sounding-rocket platform targeting roughly two minutes of microgravity.