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Newborn Dried Blood Spot PCR Reliably Detects Congenital CMV, Study Finds

PCR on routine newborn blood spots performs comparably to urine or saliva tests for identifying infants needing follow-up.

Overview

  • The JAMA Network Open study from the University of Minnesota reports that dried blood spot testing detects over 90% of symptomatic congenital CMV cases.
  • Researchers say the approach effectively flags babies most likely to benefit from early interventions and ongoing developmental monitoring.
  • Using the existing heel-prick sample avoids extra specimen collection, reducing time, cost, and stress for families compared with urine or saliva testing.
  • Minnesota began universal newborn screening for cCMV in 2023, and study co-author Mark Schleiss says the new data supports broader universal testing.
  • Authors report funding from the CDC Emerging Infections Program and the March of Dimes, with disclosed relationships noted, and contextualize cCMV as occurring in about 1 in 200 births with roughly 20% facing long-term problems.