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Maternal Age and Genetics Linked to Skewed Birth Sex Ratios

Biases tied to maternal age as well as NSUN6 and TSHZ1 variants have been confirmed by the latest analysis; a larger Swedish population study failed to find similar patterns.

Overview

  • Analysis of 58,007 U.S. nurses born between 1956 and 2015 shows families with three boys have a 61% chance of another boy and those with three girls have a 58% chance of another girl.
  • Women aged 29 or older at first birth face about a 13% higher likelihood of having all male or all female children compared to those under 23.
  • Genomic screening identified a variant in NSUN6 on chromosome 10 linked to daughters and a variant near TSHZ1 on chromosome 18 linked to sons as influencing offspring sex.
  • Excluding last births to control for parental stopping behavior did not eliminate same-sex clustering, underscoring the robustness of maternal and genetic biases.
  • Critics led by Brendan Zietsch cite a Swedish population cohort that failed to replicate these findings, prompting calls for broader, more diverse studies that include paternal data.