Overview
- UT Health San Antonio researchers reported in Aging and Disease that once-daily oral dosing for 30 days began before symptoms in both beta-amyloid and tau mouse models.
- The combination outperformed low-dose THC alone on learning and memory tests and lowered beta-amyloid, tau, and neuroinflammation measures.
- Mice received 3 mg/kg THC and 1 mg/kg celecoxib per day, roughly equal to 18 mg THC and 6 mg celecoxib for a 165-pound person.
- Single-cell RNA sequencing indicated gene-expression shifts toward healthier synaptic function and reduced inflammatory signaling after the combined therapy.
- Scientists emphasize the findings are preclinical in mice and plan studies on post-symptom treatment and safety given past concerns with COX-2 inhibitors.