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James Van Der Beek’s Death Refocuses Attention on Early-Onset Colorectal Cancer, Now the Leading Cancer Killer Under 50

Medical groups press adults to begin screening at 45 to counter rising late-stage diagnoses in younger patients.

Overview

  • The Dawson’s Creek actor died at 48 less than two and a half years after a stage 3 colorectal cancer diagnosis, and he had publicly urged screening and attention to subtle symptoms.
  • The American Cancer Society reported in January that colorectal cancer is now the top cause of cancer death for Americans under 50, with mortality in that group rising about 1.1% annually since 2005.
  • Experts project more than 150,000 new U.S. colorectal cancer cases in 2026 and about 55,000 deaths, including roughly 108,860 colon and 49,990 rectal cancer diagnoses.
  • Guidelines call for average-risk adults to start at 45, with earlier evaluation for those with symptoms or higher risk; stool- and blood-based tests are options, but any positive result requires a follow-up colonoscopy, which remains the gold standard amid persistent screening gaps.
  • Doctors urge prompt evaluation for rectal bleeding, bowel changes, abdominal pain, unexplained anemia or weight loss, noting survival is far higher when cancer is found early (about 91% for localized disease versus roughly 13% after distant spread).