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Howie Mandel Reveals Grandson Axel’s Leukemia Battle, Now in Remission After Sister’s Bone Marrow Transplant

The interview offers context for precautions taken during his treatment.

Overview

  • Mandel and his daughter, Jackelyn Shultz, disclosed the yearslong private struggle on In Depth with Graham Bensinger in their first on-camera discussion of Axel’s illness.
  • Axel, 9, was diagnosed during a family trip to Hawaii and received his first chemotherapy within 24 hours of diagnosis.
  • He is in remission following a bone marrow transplant from his 11-year-old sister, Abbey, though recovery remains prolonged.
  • Mandel said Axel still lacks a functioning immune system and cannot attend school as the family works to rebuild his immunity.
  • Shultz addressed past criticism for wearing a mask on their podcast, explaining it was to protect her hospitalized son, and Mandel noted they leaned on friends like Byron Allen and Jimmy Kimmel for support.