Overview
- Four cases were reported in Chad, four in Ethiopia and two in South Sudan in 2025, a 33% decline from 15 human cases in 2024.
- Animal infections continue to complicate eradication, with Cameroon reporting 445, Chad 147, Angola 70, Mali 17, South Sudan 3 and Ethiopia 1, reflecting slight overall growth despite declines in some countries.
- Angola, Cameroon, the Central African Republic and Mali reported zero human cases for the second consecutive year.
- The Carter Center’s next phase focuses on developing diagnostic tests, especially for animals, to detect infections before symptoms and prevent contamination of water sources.
- Field work with WHO and national ministries continues through volunteer networks, rapid case-rumor investigations and water filtration efforts, in a campaign with no medical treatment that would join smallpox as one of only two eradicated human diseases.