Overview
- The method uses a single capillary drop dried on paper cards, enabling simple shipping by mail without refrigeration.
- In 337 participants across seven European centers, p‑tau217 from finger-prick samples closely matched venous blood and cerebrospinal fluid assessments.
- GFAP and NfL were also measured reliably from dried samples, showing strong concordance with conventional diagnostics.
- Many volunteers performed the collection without clinical supervision, indicating feasible self-sampling for remote or large-scale screening.
- Findings included a Down syndrome subgroup, which showed higher p‑tau217 and GFAP levels consistent with established Alzheimer risk profiles.