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Experts Flag Nutrition Risks With GLP-1 Weight-Loss Drugs

Clinicians call for routine diet assessment to prevent deficiencies from reduced intake.

Overview

  • An HMRI systematic review reported that most trials of GLP-1 and related therapies did not document what participants ate, obscuring nutrition-related outcomes.
  • Nutrition experts, including Clare Collins, warn that appetite suppression can lower protein, fiber, vitamin and mineral intake, raising indirect deficiency risks such as vitamin C shortfall.
  • Researchers emphasize there is no evidence the drugs directly cause scurvy, though susceptible individuals could develop it if vitamin C intake falls too low.
  • Guidance includes involving accredited dietitians, using validated dietary assessment in trials and care, and considering targeted multivitamin or mineral supplements for some patients.
  • Early deficiency signs can be overlooked because fatigue, nausea and poor appetite resemble drug side effects, and Cleveland Clinic notes scurvy’s severe manifestations including anemia and bleeding gums.