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Eric Dane, 'Grey's Anatomy' Actor Who Played 'McSteamy,' Dies at 53 of ALS

His portrayal of Mark Sloan transformed a planned cameo into a character arc that redefined the series' emotional core.

Overview

  • Dane publicly disclosed his amyotrophic lateral sclerosis diagnosis in 2025.
  • He appeared in 145 episodes of the ABC medical drama, according to IMDb.
  • Introduced in Season 2 as a charismatic foil, Mark Sloan developed into a figure critics now describe as an emotional anchor.
  • His screen partnership with Lexie Grey grew into a fan-favorite thread that influenced the show's long-term storytelling.
  • In later years he also appeared on HBO's Euphoria, reflecting a career that bridged broadcast and premium television.