Overview
- Five teams received Round-of-16 byes: Deportivo Toluca, Inter Miami, Seattle Sounders, LD Alajuelense and Mount Pleasant.
- Notable first-round matchups include LA Galaxy vs Sporting San Miguelito, San Diego FC vs Pumas UNAM and Vancouver FC vs Cruz Azul, with LAFC drawing Real España.
- Vancouver Whitecaps will play CS Cartaginés for a chance to meet Seattle, whose March home leg will not be at Lumen Field due to World Cup grass installation, with an alternate venue to be confirmed.
- Concacaf set the calendar with the Round of 16 in March, quarterfinals and semifinals in April and May, and a single-match final on May 30.
- The champion earns a place in the 2026 FIFA Intercontinental Cup and the 2029 FIFA Club World Cup and will receive more than US$5 million.