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Christina Applegate’s Memoir Lays Bare Severe MS Struggles, From Dangerous Weight Loss to Muscle Wasting

The disclosures arrive as she debuts an online support hub for others living with MS.

Overview

  • The memoir, You With the Sad Eyes, is published Tuesday after excerpts and interviews appeared in recent days.
  • Applegate recounts intensive steroid treatment and a roughly 40‑pound gain, followed by a clear‑liquid diet and a loss of 50 pounds or more within seven months.
  • She attributes the rapid loss to MS‑related gastrointestinal problems and says certain foods now risk sending her back to the ER.
  • She reports more than 30 hospitalizations since 2021 and describes severe leg muscle loss that makes walking feel unsafe.
  • Despite periods confined to bed, she says she maintains small routines like taking her daughter to school and has launched the Next in MS community.