Overview
- Head coach Jim Harbaugh said Monday that Hampton was placed on injured reserve and must miss at least four games, making Week 10 on November 9 the earliest possible return.
- The first-round pick injured his left ankle during the Week 5 loss to Washington and was seen afterward in a walking boot.
- Los Angeles already lost Najee Harris to a season-ending Achilles tear, leaving Hassan Haskins and Kimani Vidal as the primary options with Amar Johnson on the practice squad.
- Hampton emerged as a key dual-threat, totaling 314 rushing yards, two touchdowns, and 20 receptions for 136 yards through five games.
- The Chargers visit Miami in Week 6 before games against the Colts, Vikings, and Titans, and Harbaugh indicated the team will explore outside help for the depleted backfield.