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Brain Stimulation Lifts Math Performance in Underconnected Adults, Sets Safety and Ethics Agenda

Researchers will soon evaluate this technique’s safety, ethics, feasibility, applicability beyond laboratory conditions.

Overview

  • A PLOS Biology study of 72 adults showed that baseline connectivity among the dlPFC, PPC and hippocampus predicts calculation learning but not memorization outcomes.
  • Mild transcranial random noise stimulation (tRNS) to the dorsolateral prefrontal cortex boosted calculation scores by 25–29 percent in participants with weaker neural connections, with no significant gains for high performers.
  • Magnetic resonance spectroscopy linked the learning improvements to interactions between tRNS-induced neuron excitability and GABAergic modulation alongside glutamate levels.
  • The findings suggest a brain-based intervention could help counter the Matthew effect by narrowing math achievement gaps rooted in innate neurobiology.
  • Researchers are now preparing to test the approach’s safety, ethical considerations, feasibility, applicability beyond laboratory conditions.